Abstract :This report describes a unique case of a young Middle Eastern female presented with 3 - 4 years history of non specific complaints including headache, fatigue, dizziness, poor appetite, irregular menses, sense of suffocation, weight loss and transient right knee joint painful swelling. On examination, she was found to have high BP measurement at right upper limb with low BP measurement at left upper limb, weak left radial pulse with left subclavian and abdominal bruits. Computed Tomography angiographic examination of the aorta showed multiple lesions at aorta and its major branches ranging from aneurysmal dilatation through attenuation, stenosis into total occlusion with diagnosis of Takayasu arteritis. She responded well to treatment with steroid and renal artery stenting.